Mitochondrial Arrest on the Microtubule HighwayA Feature Biology Diagrams
Mitochondrial Arrest on the Microtubule HighwayA Feature Biology Diagrams In turn p21 can cause G1 arrest, whereas Bax can cause apoptosis II. Also, I discuss that mitotic depletion of short-lived proteins collaborates with mitotic phosphorylation of p53, Bcl-2 and BclxL. Finally this article clarifies notions of apoptosis-prone and -reluctant cells and mitotic catastrophe. For example, increased expression of mitotic arrest deficient 2 (Mad2)-interacting protein p31 comet causes cellular senescence, which is accompanied by mitotic catastrophe . Such combination of drugs causes prolonged arrest of the cell cycle in the G2/M phase, accumulation of micronuclei, and chromosomal aberrations indicative of mitotic Prolonged mitotic arrest with the same drugs causes apoptosis during mitotic arrest in apoptosis-sensitive cell lines; in less sensitive lines, cells undergo slippage without division into tetraploid G1, which may be followed by p53-dependent arrest, apoptosis, or another round of mitosis (Rieder and Maiato, 2004; Gascoigne and Taylor, 2008
Suppression of mitotic telomere damage by enhanced expression of TRF2, or the inhibition of either caspase-3/7 or DNA-PK during mitotic arrest, promotes subsequent cell survival. Microtubule inhibitors such as paclitaxel, vincristine and nocodazole cause mitotic arrest. Cell fate determination during mitotic arrest may seem like a puzzle. If a cell cannot exit mitosis, 1it undergoes apoptosis.-4 On the other hand, apoptosis may require mitotic 2,5,6exit. Apoptosis is often p53-independent but can be p53-dependent.1,6-12 Induced cell cycle arrest is the use of a chemical or genetic manipulation to artificially halt progression through the cell cycle.Cellular processes like genome duplication and cell division stop. [1] It can be temporary or permanent. [1] It is an artificial activation of naturally occurring cell cycle checkpoints, induced by exogenous stimuli controlled by an experimenter.
Prolonged mitotic arrest triggers partial activation of apoptosis ... Biology Diagrams
In this cell line, the ablation of the 14-3-3-ฯ locus also abolishes the G2 arrest and causes mitotic catastrophe linked to the premature entry of cyclin B/Cdk1 into the nucleus (Chan et al., 1999). While recovery from transient drug treatment and mitotic progression with extra centrosomes is associated with some degree of mitotic arrest , possibly predisposing cells to telomeric DNA damage as described above, premature satisfaction or inhibition of the SAC also causes lagging chromosomes and micronucleus formation without detectable
